Groundbreaking Study Reveals PMOS Quadruples Women’s Heart Disease Risk
A groundbreaking new study published in The Lancet Obstetrics, Gynaecology & Women’s Health has discovered that women diagnosed with polyendocrine metabolic ovarian syndrome (PMOS) — formerly known as polycystic ovary syndrome (PCOS) — face a fourfold higher risk of developing cardiovascular disease compared to women without the condition.
The research, conducted by scientists at the Perelman School of Medicine at the University of Pennsylvania and the University of Rochester Medicine, is the largest of its kind in the United States. It compiled health insurance data from over 413,000 women with PMOS and compared them with more than 2 million women without the condition, spanning the period from 2000 to 2022.
Remarkably, the elevated heart disease risk persisted even after researchers accounted for known risk factors such as obesity, high blood pressure, high cholesterol, and diabetes. This suggests that PMOS independently contributes to cardiovascular danger. Over a 10-year window, approximately 12% of the PMOS group developed heart or artery disease, compared to a mere 4% in the comparison group.
The study’s authors emphasize the urgent need for early heart health screening for individuals with PMOS. Preventive measures such as weight management, a healthy diet, and regular physical activity are also recommended. The World Health Organization and the Endocrine Society officially renamed the condition from PCOS to PMOS in May 2026 to better reflect its extensive hormonal and metabolic impacts.
Source: Healthline — PMOS (Formerly PCOS) May Quadruple Risk of Heart Attack, Stroke